Based on our in vitro, ex vivo and in vivo data we want explore in preclinical setting the role of NK cells in melanoma patients treated with imitinib mesilate (anti CTLA-4 mAbs) or with anti PDL-1 antibodies the NK cells response.
Moreover, we recently defined a NK subpopulation resident in the melanoma infiltrated sentinel lymph nodes that correlate with melanoma patient’s prognosis. We want clarify the biological property of this NK cells subsets and explore the possibility to use it in biology therapy approaches of melanoma patients.
12 years – Docent of Pathology within the Medicine and Surgery graduation course (UMG)
7 years Docent of Pathology Nursery School (UMG)
12 years Docent of the International PhD program in Molecular Oncology, Experimental Immunology and development of New Therapy
7 years co-director of the International joint PhD course UMG-KI
18 years serving as docent of the “Ruggero Ceppellini” Advanced Immunology School.
Since 2000 I am Faculty member of the International Experimental Immunology PhD program (University of Catanzaro Magna Graecia – Karolinska Institutet), and the Molecular Oncology, Immunology and New Therapy Development (University Magna Graecia, Karolinska Institutet, University of Friburg and Roswell Cancer Park). Within these PhD programs, together with Professor Petter Höglund (Karolinska Institutet), I have organised and directed a Joint Course (UMG-KI) 2002, 2003, 2005, 2007. The venue of the Course was alternatively Catanzaro, Freiburg and Stockholm. The 2002-2004 editions were on Tumor biology with special focus on innate immunological surveillance and immunotherapy of cancer, while the 2006 edition was focusing on Combined anticancer therapy. All the Courses organized within the UMG-KI Joint PhD program have the standard time of 1 week full time course, student group project work and with a written final examination. The students that pass the final examination receive 1 credit (CFU). The good results obtained with our joint PhD course is largely due to the mix between basic science and clinical problems, and I believe that our didactic work is new and original. The faculty of the Joint PhD Course and program is formed by supervising PIs from both side (UMG and KI). The Italian PhD student of the UMG-KI international PhD program must spend at least one year in the partner laboratory.
Full Professor at University of Catanzaro Magna Graecia, Italy